HRID1836144

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=Cc1[nH]c2c(c1CCCN1CCN(C(=O)CO)CC1)CCCC2

HCID23498835

未命名化合物

HCID23498854

未命名化合物

PRODUCTS

生成物

结构：CCS(=O)(=O)c1ccc2c(c1)/C(=C/c1[nH]c3c(c1CCCN1CCN(C(=O)CO)CC1)CCCC3)C(=O)N2

HCID44299233

未命名化合物

收率 28.4%

PROCEDURE

实验过程

3-{3-[4-(2-Hydroxy-acetyl)-piperazin-1-yl]-propyl}-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (134 mg, 0.3 mmol), prepared as described in Example 13, was condensed with 5-ethylsulfonyloxindole (102 mg, 72% pure) following the procedure used in Example 1. Dark solid was precipitated out and purified by flash chromatography, eluting with (dichloromethane/methanol 10/1) to give 46 mg of the desired product.

WORKUP

后处理

customDark solid was precipitated out
custompurified by flash chromatography
washeluting with (dichloromethane/methanol 10/1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1d04c1479ec0410783b5272d099b13cb
来源数据集: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06777417B2
来源说明: uspto-grants-2004_08

反应 SMILES

[OH:1][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][CH2:13][C:14]2[C:22]3[CH2:21][CH2:20][CH2:19][CH2:18][C:17]=3[NH:16][C:15]=2[CH:23]=O)[CH2:7][CH2:6]1)=[O:4].[CH2:25]([S:27]([C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][C:34](=[O:39])[CH2:33]2)(=[O:29])=[O:28])[CH3:26]>>[CH2:25]([S:27]([C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][C:34](=[O:39])/[C:33]/2=[CH:23]\[C:15]1[NH:16][C:17]2[CH2:18][CH2:19][CH2:20][CH2:21][C:22]=2[C:14]=1[CH2:13][CH2:12][CH2:11][N:8]1[CH2:9][CH2:10][N:5]([C:3](=[O:4])[CH2:2][OH:1])[CH2:6][CH2:7]1)(=[O:28])=[O:29])[CH3:26]