HCID 23498835, compound → 5-Ethanesulfonyl-3-[1-(3-{3-[4-(2-hydroxyacetyl)-piperazin-1-yl]-propyl}-4,5,6,7-tetrahydro-1h-indol-2-yl)-meth-(z)-ylidene]-1,3-dihydro-indol-2-one

Participants

Reaction Steps

3-{3-[4-(2-Hydroxy-acetyl)-piperazin-1-yl]-propyl}-4,5,6,7-tetrahydro-1H-indole-2-carbaldehyde (134 mg, 0.3 mmol), prepared as described in Example 13, was condensed with 5-ethylsulfonyloxindole (102 mg, 72% pure) following the procedure used in Example 1. Dark solid was precipitated out and purified by flash chromatography, eluting with (dichloromethane/methanol 10/1) to give 46 mg of the desired product.

Provenance & Evidence