Potassium Carbonate → HCID 23498825, compound

HRID 1836149Notes

Reaction equation

HRID 1836149 reaction equation
C([O:3][C:4](=[O:26])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]2[C:23]3[CH2:22][CH2:21][CH2:20][CH2:19][C:18]=3[NH:17][C:16]=2[CH:24]=[O:25])[CH2:8][CH2:7]1)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH:24]([C:16]1[NH:17][C:18]2[CH2:19][CH2:20][CH2:21][CH2:22][C:23]=2[C:15]=1[CH2:14][CH2:13][CH2:12][N:9]1[CH2:10][CH2:11][N:6]([CH2:5][C:4]([OH:26])=[O:3])[CH2:7][CH2:8]1)=[O:25]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86588564(4-[3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazin-1-yl}-acetic acid ethyl ester

Product 1

HCID 23498825HCID 23498825, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

{(4-[3-(2-Formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazin-1-yl}-acetic acid ethyl ester (80 mg), prepared as described in example 17, was treated with potassium carbonate (38 mg, 1 mmol) in methanol/water (6/1) at room temperature for over night. The reaction solution was rotary evaporated and the residue was washed with dichloromethane/methanol (10/1) 3 times. The combined organic solution was concentrated till dryness to give {(4-[3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazin-1-yl}-acetic acid.

Workup

  1. customThe reaction solution was rotary evaporated
  2. washthe residue was washed with dichloromethane/methanol (10/1) 3 times
  3. concentrationThe combined organic solution was concentrated till dryness

Sources & evidence

ORD record
ord-c7d30d270b914b279ba89c8995bc1aef
Source dataset
uspto-grants-2004_08
Patent number
US06777417B2

Reaction notes

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