反应详情

{(4-[3-(2-Formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazin-1-yl}-acetic acid ethyl ester (80 mg), prepared as described in example 17, was treated with potassium carbonate (38 mg, 1 mmol) in methanol/water (6/1) at room temperature for over night. The reaction solution was rotary evaporated and the residue was washed with dichloromethane/methanol (10/1) 3 times. The combined organic solution was concentrated till dryness to give {(4-[3-(2-formyl-4,5,6,7-tetrahydro-1H-indol-3-yl)-propyl]-piperazin-1-yl}-acetic acid.

1. customThe reaction solution was rotary evaporated
2. washthe residue was washed with dichloromethane/methanol (10/1) 3 times
3. concentrationThe combined organic solution was concentrated till dryness