Piperidin-4-ol → HCID 23498858, compound

HRID 1836152Notes

Reaction equation

HRID 1836152 reaction equation
C(OC(N1[CH2:13][CH2:12][N:11]([C:14](=[O:27])[CH2:15][CH2:16][C:17]2[C:25]3[C:24](=[O:26])[CH2:23][CH2:22][CH2:21][C:20]=3[NH:19][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.N1CC[CH:31]([OH:34])CC1>>[OH:34][CH:31]1[CH2:9][CH2:10][N:11]([C:14](=[O:27])[CH2:15][CH2:16][C:17]2[C:25]3[C:24](=[O:26])[CH2:23][CH2:22][CH2:21][C:20]=3[NH:19][CH:18]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 69839741HCID 69839741, compound

Product 1

HCID 23498858HCID 23498858, compound

Procedure

3-[3-(4-Hydroxy-piperidin-1-yl)-3-oxo-propyl]-1,5,6,7-tetrahydro-indol-4-one was prepared by following the procedure described for the synthesis of 4-[3-(4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)-propionyl]-piperazine-1-carboxylic acid tert-butyl ester (Step 1 of example 8) by substituting tert-butyl 1-piperazinecarboxylate with piperidin-4-ol.

Sources & evidence

ORD record
ord-ae9c7c4f456c4508a64572036a9cbe66
Source dataset
uspto-grants-2004_08
Patent number
US06777417B2

Reaction notes

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