Ammonia → HCID 10448521, compound

HRID 1836198Notes

Reaction equation

HRID 1836198 reaction equation
N.C([O:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:15](=[O:16])[CH:14]=[C:13]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[C:20]([CH2:25][CH3:26])[CH:19]=2)[NH:12][C:11]1=[O:27])(=O)C>CO>[OH:5][CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[C:15](=[O:16])[CH:14]=[C:13]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[C:20]([CH2:25][CH3:26])[CH:19]=2)[NH:12][C:11]1=[O:27]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 10309080HCID 10309080, compound

Product 1

HCID 10448521HCID 10448521, compoundYield 118.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Aqueous concentrated ammonia (150 ml) was added to a stirred suspension of 3-(4-acetoxybutyl)-6-(3-ethyl-4-methylanilino)uracil (10.5 g, 24 mmol) in 150 ml of methanol at room temperature. After 30 minutes, all solid was dissolved, and the solution was stirred for 72 hours. The solvent was removed, and the solid was co-evaporated three times with methanol, and filtered from methanol to give the product as a white solid (9.0 g, 97%).

Workup

  1. dissolutionall solid was dissolved
  2. customThe solvent was removed
  3. filtrationfiltered from methanol

Sources & evidence

ORD record
ord-2f52d47844a14908a4f296a82af06f13
Source dataset
uspto-grants-2004_08
Patent number
US06777420B2

Reaction notes

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