HCID 23518325, compound → HCID 23518327, compound

HRID 1836231Notes

Reaction equation

HRID 1836231 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([Cl:35])[C:5]2[CH:10]=[CH:9][N:8]([C@@H:11]3[O:26][C@H:25]([CH2:27][O:28][CH:29]4[CH2:34][CH2:33][CH2:32][CH2:31][O:30]4)[C@@H:17]([O:18][CH:19]4[CH2:24][CH2:23][CH2:22][CH2:21][O:20]4)[C@@H:12]3[O:13]C(=O)C)[C:6]=2[N:7]=1>N>[NH2:1][C:2]1[N:3]=[C:4]([Cl:35])[C:5]2[CH:10]=[CH:9][N:8]([C@@H:11]3[O:26][C@H:25]([CH2:27][O:28][CH:29]4[CH2:34][CH2:33][CH2:32][CH2:31][O:30]4)[C@@H:17]([O:18][CH:19]4[CH2:24][CH2:23][CH2:22][CH2:21][O:20]4)[C@@H:12]3[OH:13])[C:6]=2[N:7]=1

Participants

3

Reactant 1

HCID 23518325HCID 23518325, compound

Product 1

HCID 23518327HCID 23518327, compoundYield 100.6%

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A mixture of the compound from Step F (0.27 g, 0.53 mmol) and methanolic ammonia (saturated at 0° C.; 10 mL) was kept overnight at 0° C. Evaporation of the solvent yielded the desired compound (0.25 g).

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-1a3fe742a3eb48b8826c620b8461b14e
Source dataset
uspto-grants-2004_08
Patent number
US06777395B2

Reaction notes

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