Hydrochloric Acid → HCID 178478526, compound

HRID 1836305Notes

Reaction equation

HRID 1836305 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[N:9][CH:8]=2)[N:3]=[CH:2]1.[ClH:17]>CO.O1CCOCC1>[ClH:17].[ClH:17].[NH:1]1[CH:5]=[C:4]([CH2:6][C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[N:9][CH:8]=2)[N:3]=[CH:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178419932HCID 178419932, compound

Product 1

HCID 178478526HCID 178478526, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To 4-(1H-Imidazol-4-yl-methyl)-isoquinoline (0.053 g, 0.253 mmol) in 5 ml methanol, 3 ml of HCl in dioxane was added and the reaction mixture was concentrated under reduced pressure to give 0.071 g, (100%) of the product as a solid. Anal. Calcd. for C13H≦N3Cl2 1.3 mole H2O: C, 51.10; H, 5.15; N, 13.75. Found: C, 51.27; H, 4.97; N, 13.54.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d3133dd48ec3400780e58e516f61540d
Source dataset
uspto-grants-2004_08
Patent number
US06777426B2

Reaction notes

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