2-Methoxybenzoyl chloride → 4-[3-(2-Methoxybenzamidyl)benzoyl]-1-methylpiperidine

HRID 1836361Notes

Reaction equation

HRID 1836361 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([CH:7]1[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:6].[CH3:17][O:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22]>>[CH3:17][O:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([NH:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([CH:7]1[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12]1)=[O:6])=[O:22]

Participants

3

Reactant 2

HCID 889692-Methoxybenzoyl chlorideHCID 101306514-[3-Aminobenzoyl]-1-methylpiperidine

Product 1

HCID 235188144-[3-(2-Methoxybenzamidyl)benzoyl]-1-methylpiperidineYield 78%

Procedure

Beginning with 4-[3-aminobenzoyl]-1-methylpiperidine (50 mg, 0.229 mmol) and 2-methoxybenzoyl chloride (102 μl, 0.685 mmol), 62.6 mg (78%) of the title compound were recovered.

Sources & evidence

ORD record
ord-d549d9fee97d411eaf7a586bbe6b95db
Source dataset
uspto-grants-2004_08
Patent number
US06777428B1

Reaction notes

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