2,3,6-Trifluorobenzoyl chloride → 4-[3-(2,3,6-Trifluorobenzamidyl)benzoyl]-1-methylpiperidine

HRID 1836394Notes

Reaction equation

HRID 1836394 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([CH:7]1[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]1)=[O:6].[F:17][C:18]1[C:26]([F:27])=[CH:25][CH:24]=[C:23]([F:28])[C:19]=1[C:20](Cl)=[O:21]>>[F:17][C:18]1[C:26]([F:27])=[CH:25][CH:24]=[C:23]([F:28])[C:19]=1[C:20]([NH:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[C:5]([CH:7]1[CH2:8][CH2:9][N:10]([CH3:13])[CH2:11][CH2:12]1)=[O:6])=[O:21]

Participants

3

Reactant 2

HCID 5944072,3,6-Trifluorobenzoyl chlorideHCID 101306514-[3-Aminobenzoyl]-1-methylpiperidine

Product 1

HCID 693558534-[3-(2,3,6-Trifluorobenzamidyl)benzoyl]-1-methylpiperidine

Procedure

Beginning with 4-[3-aminobenzoyl]-1-methylpiperidine (25 mg, 0.115 mmol) and 2,3,6-trifluorobenzoyl chloride (30 μL, 0.229 mmol) and mixing for 24 h, 47.7 mg (>100%) of the title compound were recovered.

Workup

  1. additionmixing for 24 h
  2. custom47.7 mg (>100%) of the title compound were recovered

Sources & evidence

ORD record
ord-293c6530f70b47c98dd51f9e9dad59f5
Source dataset
uspto-grants-2004_08
Patent number
US06777428B1

Reaction notes

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