反应详情

温度

70 °C

A suspension of 6-bromo-N-(4-fluoro-phenyl)nicotinamide (1.0 g, 3.4 mmol), methyl glycolate (1.6 mL, 19 mmol), and potassium tert-butoxide (1.5 g, 10 13.6 mmol) in THF (10 mL) was heated in a sealed tube at 70° C. After 3 h the reaction mixture was poured onto ice and the solids isolated by filtration. Purification on silica gel by column chromatography using 30% ethyl acetate in hexanes gave 0.68 g (65%) of the titled product as a white solid:

1. additionAfter 3 h the reaction mixture was poured onto ice
2. customthe solids isolated by filtration
3. customPurification on silica gel by column chromatography