3-Fluorobenzaldehyde → HCID 73855580, compound

HRID 1836471Notes

Reaction equation

HRID 1836471 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.Cl.[O:11]([NH2:13])[CH3:12]>>[CH3:12][O:11][N:13]=[CH:5][C:4]1[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[CH:3]=1

Participants

3

Reactant 2

HCID 680093-FluorobenzaldehydeHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 73855580HCID 73855580, compoundYield 94%

Procedure

Reaction of 3-fluorobenzaldehyde with methoxylamine hydrochloride as described in the preparation of compound 3-A gave the title oxime ether as a clear oil. (94% yield). HPLC indicated a 88:12 mixture of E- and Z-isomer. 1HNMR 400 MHz (CDCl3) δ (ppm): (E-isomer) 3.98 (3H, s, OCH3), 7.03-7.08 (2H, m, aromatics), 7.26-7.36 (2H, m, aromatics), 8.02 (1H, s, CH).

Sources & evidence

ORD record
ord-8ff0186d9a4b4abca50296b83d4785f7
Source dataset
uspto-grants-2004_08
Patent number
US06777440B2

Reaction notes

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