o-Fluorobenzaldehyde → HCID 73855582, compound

HRID 1836474Notes

Reaction equation

HRID 1836474 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[O:11]([NH2:13])[CH3:12]>>[CH3:12][O:11][N:13]=[CH:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[F:1]

Participants

3

Reactant 2

HCID 67970o-FluorobenzaldehydeHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 73855582HCID 73855582, compoundYield 98%

Procedure

Reaction of 2-fluorobenzaldehyde with methoxylamine hydrochloride as described in the preparation of compound 3-A gave the title oxime ether as a clear oil (98% yield). HPLC indicated a 91:9 mixture of E- and Z-isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): (E-isomer) 3.99 (3H, s, OCH3), 7.07 (1H, m, aromatic), 7.14 (1H, m, aromatic), 7.34 (1H, m, aromatic), 7.82 (1H, m, aromatic), 8.31 (1H, s, CH).

Sources & evidence

ORD record
ord-a3a2a76cc9af4805adbdb7021b8c75b0
Source dataset
uspto-grants-2004_08
Patent number
US06777440B2

Reaction notes

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