O-Methylhydroxylamine hydrochloride → HCID 73855576, compound

HRID 1836477Notes

Reaction equation

HRID 1836477 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]=O)=[CH:4][CH:3]=1.Cl.[O:12]([NH2:14])[CH3:13]>>[CH3:13][O:12][N:14]=[CH:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 111263222-(4-Fluorophenyl)acetaldehyde

Product 1

HCID 73855576HCID 73855576, compoundYield 43%

Procedure

Reaction of 4-fluorophenylacetaldehyde with methoxylamine hydrochloride as described in the preparation of compound 3-A gave the title oxime ether as a clear oil (43% yield). 1HNMR indicated a 1:1 mixture of E- and Z-isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): 3.51 (2H, d, J=6.7 Hz, CH2), 3.66 (2H, d, J=5.5 Hz, CH2), 3.88 (3H, s, OCH3), 3.96 (3H, s, OCH3), 6.79 (1H, t, J=5.5 Hz, CH), 7.03 (2H, m, aromatics), 7.19 (2H, m, aromatics), 7.45 (1H, t, J=6.7 Hz, CH).

Sources & evidence

ORD record
ord-fe127c3598a645c48eb6348345c35860
Source dataset
uspto-grants-2004_08
Patent number
US06777440B2

Reaction notes

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