O-Methylhydroxylamine hydrochloride → HCID 73988966, compound

HRID 1836519Notes

Reaction equation

HRID 1836519 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[CH3:10])[CH:5]=O.Cl.[O:12]([NH2:14])[CH3:13]>>[CH3:13][O:12][N:14]=[CH:5][C:4]1[CH:7]=[CH:8][C:9]([CH3:10])=[C:2]([F:1])[CH:3]=1

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 27745743-Fluoro-4-methylbenzaldehyde

Product 1

HCID 73988966HCID 73988966, compoundYield 94%

Procedure

Reaction of 3-fluoro-4-methyl-benzaldehyde with methoxylamine hydrochloride as described in the preparation of compound 3-A gave the title oxime ether as a clear oil (94% yield). 1HNMR indicated a 9:1 mixture of E- and Z-isomers. 1HNMR 400 MHz (CDCl3) δ (ppm): (E-isomer) 2.28 (3H, broad s, CH3), 3.97 (3H, s, OCH3), 7.15-7.29 (3H, m, aromatics), 7.99 (1H, s, CH).

Sources & evidence

ORD record
ord-6a8931cac8fc4c339d3400aa86fa2db0
Source dataset
uspto-grants-2004_08
Patent number
US06777440B2

Reaction notes

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