Hydrochloric Acid → ethyl (2S)-2-amino-3-phenylmethoxypropanoate;hydrochloride

Participants

Reaction Steps

A solution of O-benzyl-L-serine (9.75 g, 50 mmol) in ethanol (200 mL) is saturated with HCl gas for 8 minutes. The mixture is stirred overnight at room temperature, and then concentrated in vacuo. The solid is washed with diethyl ether and collected by filtration to yield O-benzyl-L-serine ethyl ester hydrochloride as a white solid.

Provenance & Evidence