Hydrochloric Acid → Ethyl 4-(4-chloro-1-oxobutyl)-alpha,alpha-dimethylbenzeneacetate

HRID 1836779Notes

Reaction equation

HRID 1836779 reaction equation
Cl.[Cl:2][CH2:3][CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]([CH3:19])([CH3:18])[C:15]([OH:17])=[O:16])=[CH:10][CH:9]=1)=[O:7].[CH2:20](O)[CH3:21]>>[Cl:2][CH2:3][CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]([CH3:19])([CH3:18])[C:15]([O:17][CH2:20][CH3:21])=[O:16])=[CH:10][CH:9]=1)=[O:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 109235672-(4-(4-Chlorobutanoyl)phenyl)-2-methylpropanoic acid

Product 1

HCID 11231785Ethyl 4-(4-chloro-1-oxobutyl)-alpha,alpha-dimethylbenzeneacetateYield 97%

Procedure

Add anhydrous hydrogen chloride gas (18.0 g) to anhydrous ethanol DB (210 g) by purging the solution. Add this hot solution (60° C.) to a solution of 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionic acid (31 g, 115.6 mmol) and reflux under a nitrogen atmosphere for 2.5 hours. Evaporate the solvent in vacuo, dissolve the reside in methylene chloride (150 mL) and wash with water (2×100 mL). Dry (MgSO4), filter through silica gel, washing the gel with methylene chloride (250 mL). Combine the organic washings and evaporate the solvent in vacuo to give the title compound as a colorless oil (33.3 g, 97%).

Workup

  1. customby purging the solution
  2. temperaturereflux under a nitrogen atmosphere for 2.5 hours
  3. customEvaporate the solvent in vacuo
  4. dissolutiondissolve the reside in methylene chloride (150 mL)
  5. washwash with water (2×100 mL)
  6. dry with materialDry (MgSO4)
  7. filtrationfilter through silica gel
  8. washwashing the gel with methylene chloride (250 mL)
  9. customCombine the organic washings and evaporate the solvent in vacuo

Sources & evidence

ORD record
ord-b45ea6ccf5d942198039273116b6615d
Source dataset
uspto-grants-2004_08
Patent number
US06777555B2

Reaction notes

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