2,2,2-Trifluoroethylamine hydrochloride → 3-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-N-(2,2,2-trifluoroethyl)benzamide

HRID 1836809Notes

Reaction equation

HRID 1836809 reaction equation
[C:1]1([CH:7]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=3)[C:19]([OH:21])=O)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[F:32][C:33]([F:37])([F:36])[CH2:34][NH2:35]>>[C:25]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:17]=[C:18]([CH:22]=[CH:23][CH:24]=3)[C:19]([NH:35][CH2:34][C:33]([F:37])([F:36])[F:32])=[O:21])[CH2:12][CH2:11]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 97722,2,2-Trifluoroethylamine hydrochlorideHCID 221804873-[4-(3,3-Diphenyl-1-propyl)piperazin-1-yl]benzoic acid

Product 1

HCID 221806393-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-N-(2,2,2-trifluoroethyl)benzamide

Procedure

The procedure of step (d) of Example 1 was repeated using the compound prepared in step (c) of Example 1, except that 2,2,2-trifluoroethylamine hydrochloride was used instead of N-methylbenzylamine. Thus, 3-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-N-(2,2,2-trifluoroethyl)benzamide was prepared.

Sources & evidence

ORD record
ord-25a7f7550cca4b84b1d12b6820f803b2
Source dataset
uspto-grants-2004_08
Patent number
US06777414B1

Reaction notes

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