Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1836809Generated: October 30, 2026

2,2,2-Trifluoroethylamine hydrochloride → 3-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-N-(2,2,2-trifluoroethyl)benzamide

https://huagongshe.com/reaction/1836809

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,2,2-Trifluoroethylamine hydrochlorideHCID 9772—
Reactant3-[4-(3,3-Diphenyl-1-propyl)piperazin-1-yl]benzoic acidHCID 22180487—
Product3-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-N-(2,2,2-trifluoroethyl)benzamideHCID 22180639—

Reaction Steps

The procedure of step (d) of Example 1 was repeated using the compound prepared in step (c) of Example 1, except that 2,2,2-trifluoroethylamine hydrochloride was used instead of N-methylbenzylamine. Thus, 3-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-N-(2,2,2-trifluoroethyl)benzamide was prepared.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06777414B1
Source datasetuspto-grants-2004_08
ORD IDord-25a7f7550cca4b84b1d12b6820f803b2
Source noteuspto-grants-2004_08