N-Methylcyclohexylamine → n-Cyclohexyl-5-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-n-methyl-2-methylbenzamide

HRID 1836817Notes

Reaction equation

HRID 1836817 reaction equation
C(N(C1CCCCC1)C(=O)C1C=C([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH:20]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:14][CH2:13]2)C=CC=1F)C=C.[CH3:41][C:42]1[CH:50]=[CH:49][C:48]([N+]([O-])=O)=[CH:47][C:43]=1[C:44]([OH:46])=O.[CH3:54][NH:55][CH:56]1[CH2:61][CH2:60][CH2:59][CH2:58][CH2:57]1>>[CH:56]1([N:55]([CH3:54])[C:44](=[O:46])[C:43]2[CH:47]=[C:48]([N:12]3[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][CH:20]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH2:14][CH2:13]3)[CH:49]=[CH:50][C:42]=2[CH3:41])[CH2:61][CH2:60][CH2:59][CH2:58][CH2:57]1

Participants

4

Reactant 3

HCID 7514N-MethylcyclohexylamineHCID 5196832-Methyl-5-nitrobenzoic acidHCID 22180389n-Allyl-n-cyclohexyl-5-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-2-fluorobenzamide

Product 1

HCID 22180538n-Cyclohexyl-5-[4-(3,3-diphenyl-1-propyl)piperazin-1-yl]-n-methyl-2-methylbenzamide

Procedure

Steps (a) and (b) of Example 59 were repeated, except that 2-methyl-5-nitrobenzoic acid was used instead of 2-fluoro-5-nitrobenzoic acid. Step (c) of Example 59 was then repeated, except that N-methylcyclohexylamine was used instead of N-allylcyclohexylamine. Thus, the title compound was prepared.

Sources & evidence

ORD record
ord-27e5ab9e9c1e4c478c0472040644edfb
Source dataset
uspto-grants-2004_08
Patent number
US06777414B1

Reaction notes

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