HRID1836826

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(NCC(F)(F)F)C1(CCCBr)c2ccccc2-c2ccccc21

HCID10597759

未命名化合物

结构：CC(C)(C)OC(=O)N1CCN(c2ccc3c(c2)C(=O)N(CC2CCCCO2)CC3)CC1

HCID22180286

未命名化合物

PRODUCTS

生成物

结构：O=C1c2cc(N3CCN(CCCC4(C(=O)NCC(F)(F)F)c5ccccc5-c5ccccc54)CC3)ccc2CCN1CC1CCCCO1

HCID22180161

未命名化合物

PROCEDURE

实验过程

Step (b) of Example 97 was repeated, except that the compound prepared in step (a) of Example 99 and the compound prepared in step (a) of Example 93 were used as the starting compounds. Thus, the title compound was prepared.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a01982792f954e4b8f84b430ccd906ba
来源数据集: uspto-grants-2004_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06777414B1
来源说明: uspto-grants-2004_08

反应 SMILES

[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)=[CH:13][CH:14]=2)[C:9]1=[O:31].[F:32][C:33]([F:56])([F:55])[CH2:34][NH:35][C:36]([C:38]1([CH2:51][CH2:52][CH2:53]Br)[C:50]2[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=2[C:44]2[C:39]1=[CH:40][CH:41]=[CH:42][CH:43]=2)=[O:37]>>[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([N:18]3[CH2:23][CH2:22][N:21]([CH2:53][CH2:52][CH2:51][C:38]4([C:36](=[O:37])[NH:35][CH2:34][C:33]([F:32])([F:55])[F:56])[C:50]5[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=5[C:44]5[C:39]4=[CH:40][CH:41]=[CH:42][CH:43]=5)[CH2:20][CH2:19]3)=[CH:13][CH:14]=2)[C:9]1=[O:31]