3-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-fluoren-9-yl]propyl bromide → 2-(Tetrahydropyran-2-yl)methyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-fluoren-9-yl]propyl]piperazin-1-yl]-3,4-dihydro-2H-isoquinolin-1-one

Participants

Role	Name	HCID	Charge
Reactant	3-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-fluoren-9-yl]propyl bromide	HCID 10597759	—
Reactant	2-(tetrahydropyran-2-yl)methyl-7-(4-t-butoxycarbonyl-piperazin-1-yl)-3,4-dihydro-2H-isoquinolin-1-one	HCID 22180286	—
Product	2-(Tetrahydropyran-2-yl)methyl-7-[4-[3-[9-(2,2,2-trifluoroethylcarbamoyl)-9H-fluoren-9-yl]propyl]piperazin-1-yl]-3,4-dihydro-2H-isoquinolin-1-one	HCID 22180161	—

Reaction Steps

Step (b) of Example 97 was repeated, except that the compound prepared in step (a) of Example 99 and the compound prepared in step (a) of Example 93 were used as the starting compounds. Thus, the title compound was prepared.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06777414B1
Source dataset	uspto-grants-2004_08
ORD ID	ord-a01982792f954e4b8f84b430ccd906ba
Source note	uspto-grants-2004_08