反应详情

A solution of cholesteryl chloroformate (2.25 g, 5 mmol in 5 ml of dry chloroform) is added dropwise to an excess of a solution of N,N-dimethylethylenediamine (2 ml, 18.2 mmol, in 3 ml of dry chloroform) at 0° C. After extraction of the solvent by evaporation, the residue is purified by 2 successive recrystallizations in absolute ethanol at 4° C., and dried under vacuum. 0.545 g of DC chol is thereby obtained in the form of a white powder. The structure of the compound was verified by NMR and mass spectrometry. The results obtained are in agreement with the data published in the paper cited above.

1. extractionAfter extraction of the solvent
2. customby evaporation
3. customthe residue is purified by 2 successive recrystallizations in absolute ethanol at 4° C.
4. customdried under vacuum
5. custom0.545 g of DC chol is thereby obtained in the form of a white powder
6. customThe results obtained