HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(cyclobutylmethyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cyclobutylmethylamine | HCID 409746 | — |
| Reactant | 2-(Methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine | HCID 11176443 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-(cyclobutylmethyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine | HCID 9800275 | 85.7% |
Reaction Steps
A mixture of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (0.5 g, 1.314 mmol) and (cyclobutylmethyl)amine (0.24 g) in NMP (5 ml) was stirred at ambient temperature for 18 h. Water (50 ml) was then added, and the resulting precipitate was collected by filtration and dried, giving the title compound as a cream solid (0.434 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06780869B1 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-0d637b313f704f18a48e32259e9f24a1 |
| Source note | uspto-grants-2004_08 |