Water → N-(cyclobutylmethyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine

HRID 1836979Notes

Reaction equation

HRID 1836979 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=2)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=1)(=O)=O.[CH:25]1([CH2:29][NH2:30])[CH2:28][CH2:27][CH2:26]1.O>CN1C(=O)CCC1>[CH:25]1([CH2:29][NH:30][C:5]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=3)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=2)[CH2:28][CH2:27][CH2:26]1

Participants

5

Reactant 3

HCID 962WaterHCID 409746CyclobutylmethylamineHCID 111764432-(Methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine

Product 1

HCID 9800275N-(cyclobutylmethyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amineYield 85.7%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A mixture of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (0.5 g, 1.314 mmol) and (cyclobutylmethyl)amine (0.24 g) in NMP (5 ml) was stirred at ambient temperature for 18 h. Water (50 ml) was then added, and the resulting precipitate was collected by filtration and dried, giving the title compound as a cream solid (0.434 g).

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-0d637b313f704f18a48e32259e9f24a1
Source dataset
uspto-grants-2004_08
Patent number
US06780869B1

Reaction notes

Loading…