Dichloromethane → Tert-butyl 2'-methylspiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidine]-1'-carboxylate

HRID 183698Notes

Reaction equation

HRID 183698 reaction equation
[CH3:20][CH:21]1[N:22]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH2:23][CH2:24][C:25](=[O:27])[CH2:26]1.[Cl:35][CH2:36][Cl:37].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7].[n:8]1(-[c:13]2[c:14]([OH:19])[cH:15][cH:16][cH:17][cH:18]2)[cH:9][cH:10][cH:11][cH:12]1>>[n:8]12[cH:9][cH:10][cH:11][c:12]1[C:25]1([O:19][c:14]3[c:13]-2[cH:18][cH:17][cH:16][cH:15]3)[CH2:24][CH2:23][N:22]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[CH:21]([CH3:20])[CH2:26]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 7123342-(1H-Pyrrol-1-Yl)PhenolHCID 12992764tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate

Product 1

HCID 67468689Tert-butyl 2'-methylspiro[benzo[b]pyrrolo[1,2-d][1,4]oxazine-4,4'-piperidine]-1'-carboxylate

Sources & evidence

ORD record
ord-67143ccbebf849f9bd3625c0d0968b77
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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