Acetic Anhydride → 4-[4-(Methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-ylformamide

HRID 1836984Notes

Reaction equation

HRID 1836984 reaction equation
C(O[C:5](=[O:7])C)(=O)C.[CH3:8][S:9]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[N:21]=[C:20]([NH2:28])[N:19]=2)=[CH:14][CH:13]=1)(=[O:11])=[O:10]>C(O)=O>[CH3:8][S:9]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[C:22]([C:24]([F:25])([F:26])[F:27])[N:21]=[C:20]([NH:28][CH:5]=[O:7])[N:19]=2)=[CH:14][CH:13]=1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 234974714-(4-(Methylsulfonyl)phenyl)-6-(trifluoromethyl)pyrimidin-2-amine

Product 1

HCID 865883724-[4-(Methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-ylformamide

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of formic acid (7 ml) and acetic anhydride (2 ml) was stirred at 20 C for 1 h. 4-[4-(Methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine (0.5 g, 1.576 mmol) was then added and stirring was continued at ambient temperature for 18 h. This gave the title compound as a colourless precipitate which was collected by filtration and dried (0.32 g).

Workup

  1. stirringstirring
  2. waitwas continued at ambient temperature for 18 h

Sources & evidence

ORD record
ord-bd052a365cc24b7b902fb56748dd534f
Source dataset
uspto-grants-2004_08
Patent number
US06780870B2

Reaction notes

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