Acetic Anhydride → 4-[4-(Methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-ylformamide

Participants

Reaction Steps

A mixture of formic acid (7 ml) and acetic anhydride (2 ml) was stirred at 20 C for 1 h. 4-[4-(Methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine (0.5 g, 1.576 mmol) was then added and stirring was continued at ambient temperature for 18 h. This gave the title compound as a colourless precipitate which was collected by filtration and dried (0.32 g).

Provenance & Evidence