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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1836991Generated: November 3, 2026

4-Fluorobenzylamine → HCID 10180742, compound

https://huagongshe.com/reaction/1836991

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-FluorobenzylamineHCID 67326—
Reactant2-(Methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidineHCID 11176443—
SolventWaterHCID 962—
SolventN-methyl-2-pyrrolidoneHCID 13387—
ProductHCID 10180742HCID 10180742—

Reaction Steps

A stirred solution of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (1 g, 2.629 mmol) in N-methylpyrrolidone (10 ml) was treated with 4-fluorobenzylamine (0.60 ml). The mixture was stirred at room temp for 18 h and was then diluted with water (50 ml). This gave the title compound as a colourless solid which was collected by filtration and dried (0.72 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06780870B2
Source datasetuspto-grants-2004_08
ORD IDord-1c160f1c6a9a417f81d8a624a1a47cf1
Source noteuspto-grants-2004_08