4-Fluorobenzylamine → HCID 10180742, compound

HRID 1836991Notes

Reaction equation

HRID 1836991 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=2)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=1)(=O)=O.[F:25][C:26]1[CH:33]=[CH:32][C:29]([CH2:30][NH2:31])=[CH:28][CH:27]=1>CN1CCCC1=O.O>[F:25][C:26]1[CH:33]=[CH:32][C:29]([CH2:30][NH:31][C:5]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][CH:12]=3)[CH:8]=[C:7]([C:21]([F:24])([F:23])[F:22])[N:6]=2)=[CH:28][CH:27]=1

Participants

5

Reactant 2

HCID 673264-FluorobenzylamineHCID 111764432-(Methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine

Product 1

HCID 10180742HCID 10180742, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A stirred solution of 2-(methylsulfonyl)-4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)pyrimidine (1 g, 2.629 mmol) in N-methylpyrrolidone (10 ml) was treated with 4-fluorobenzylamine (0.60 ml). The mixture was stirred at room temp for 18 h and was then diluted with water (50 ml). This gave the title compound as a colourless solid which was collected by filtration and dried (0.72 g).

Sources & evidence

ORD record
ord-1c160f1c6a9a417f81d8a624a1a47cf1
Source dataset
uspto-grants-2004_08
Patent number
US06780870B2

Reaction notes

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