反应详情

2-Chloronicotinyl chloride hydrochloride (2.94 g, 16.5 mmol) was added in portions to a solution of pyridine (4.0 mL) and 4-anisidine (2.0 g, 16.2 mmol) in chloroform. After 0.5 h, the mixture was poured into EtOAc and 1 N NaOH. The organic layer was washed with 1 N NaOH (1×), water (1×), dried over potassium carbonate, and concentrated. The residue was purified by recrystallization (EtOAc:hexanes) yielding 2.56 g (60%) of the title compound.

1. washThe organic layer was washed with 1 N NaOH (1×), water (1×)
2. dry with materialdried over potassium carbonate
3. concentrationconcentrated
4. customThe residue was purified by recrystallization (EtOAc:hexanes)