反应详情

温度

0 °C

A solution of 16.2 g of 7α-(5-bromopentyl)-11β-fluoro-3-hydroxy-estra-1,3,5(10)-trien-17-one in 162 ml of tetrahydrofuran as well as 90 ml of ethanol and 36 ml of water are mixed in portions at 0° C. with 4.7 g of sodium borohydride and stirred for 2 hours at 0° C. Then, it is added to water, extracted four times with ethyl acetate, washed with water and common salt solution, dried on sodium sulfate and concentrated by evaporation in a vacuum. 17.1 g of crude product is obtained. After chromatography on silica gel with hexane/ethyl acetate, 15.6 g of pure 7α-(5-bromopentyl)-11β-fluor-estra-1,3,5(10)-triene-3,17β-diol is obtained.

1. extractionextracted four times with ethyl acetate
2. washwashed with water and common salt solution
3. customdried on sodium sulfate
4. concentrationconcentrated by evaporation in a vacuum
5. custom17.1 g of crude product is obtained