HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile → 3-Quinolinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile | HCID 23498095 | — |
| Solvent | 1-Propanol | HCID 1031 | — |
| Product | 3-Quinolinecarbonitrile | HCID 93177 | — |
Reaction Steps
Following the procedure used to prepare Example 15, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile (200 mg, 0.55 mmol) and 3-(4-methyl)piperazin-1-yl)propanol provided 71 mg of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methyl)piperazin-1-yl)propoxy]-3-quinolinecarbonitrile, mp 154-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06780996B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-6b7789442fd445a4807d497a6eca5a51 |
| Source note | uspto-grants-2004_08 |