4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile → 3-Quinolinecarbonitrile

HRID 1837375Notes

Reaction equation

HRID 1837375 reaction equation
ClC1C=C(Cl)C(OC)=CC=1N[C:12]1[C:21]2[C:16](=[CH:17][C:18](F)=[CH:19][CH:20]=2)[N:15]=[CH:14][C:13]=1[C:23]#[N:24]>C(O)CC>[N:15]1[C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:12]=[C:13]([C:23]#[N:24])[CH:14]=1

Participants

3

Reactant 1

HCID 234980954-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile

Product 1

HCID 931773-Quinolinecarbonitrile

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

Following the procedure used to prepare Example 15, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-3-quinolinecarbonitrile (200 mg, 0.55 mmol) and 3-(4-methyl)piperazin-1-yl)propanol provided 71 mg of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methyl)piperazin-1-yl)propoxy]-3-quinolinecarbonitrile, mp 154-155° C.

Sources & evidence

ORD record
ord-6b7789442fd445a4807d497a6eca5a51
Source dataset
uspto-grants-2004_08
Patent number
US06780996B2

Reaction notes

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