Ammonium Hydroxide → HCID 22677262, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4,5,6-trichloropyridine-2-carboxylate (15 g, 62.4 mmol) was suspended in concentrated aqueous ammonium hydroxide (80 mL) and methanol (150 mL). After stirring for 4 hours at 25° C., the methanol was removed and the aqueous suspension was filtered. The filter cake was washed with water and dried to provide 4,5,6-trichloropyridine-2-carboxamide (13 g, 56.9 mmol), mp 169-170° C.

Provenance & Evidence