Ammonium Hydroxide → HCID 22677262, compound

HRID 1837446Notes

Reaction equation

HRID 1837446 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[N:5]=[C:4]([C:10]([O:12]C)=O)[CH:3]=1.[OH-].[NH4+:15]>CO>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[N:5]=[C:4]([C:10]([NH2:15])=[O:12])[CH:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 12993691Methyl 4,5,6-trichloropicolinate

Product 1

HCID 22677262HCID 22677262, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

Methyl 4,5,6-trichloropyridine-2-carboxylate (15 g, 62.4 mmol) was suspended in concentrated aqueous ammonium hydroxide (80 mL) and methanol (150 mL). After stirring for 4 hours at 25° C., the methanol was removed and the aqueous suspension was filtered. The filter cake was washed with water and dried to provide 4,5,6-trichloropyridine-2-carboxamide (13 g, 56.9 mmol), mp 169-170° C.

Workup

  1. customthe methanol was removed
  2. filtrationthe aqueous suspension was filtered
  3. washThe filter cake was washed with water
  4. customdried

Sources & evidence

ORD record
ord-c0323658ce074f74945eef7a4aa8edf5
Source dataset
uspto-grants-2004_08
Patent number
US06784137B2

Reaction notes

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