反应详情

温度

20 °C

To a solution of 3-acetyl thianaphthene (2.024 g, 11.5 mmol) in ethanol (15 mL) was added sodium borohydride (0.434 g, 11.5 mmol). The mixture was stirred at 20° C. for 4 hours then evaporated, diluted with brine and extracted 3 times with ethyl acetate. The combined organics were dried over sodium sulfate, filtered and evaporated to give the intermediate title compound as a clear oil (1.924 g, 94%) which was used as is in subsequent reactions. FDMS m/e=178 (M+).

1. customthen evaporated
2. additiondiluted with brine
3. extractionextracted 3 times with ethyl acetate
4. dry with materialThe combined organics were dried over sodium sulfate
5. filtrationfiltered
6. customevaporated