Hydrochloric Acid → 1-[(Piperidin-4-yl)methyl]piperidine--hydrogen chloride (1/2)

HRID 1837492Notes

Reaction equation

HRID 1837492 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:14]>C(O)C.[Pt]=O>[ClH:14].[ClH:14].[N:1]1([CH2:7][CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 124725304-[(Piperidin-1-yl)methyl]pyridine

Product 1

HCID 226779161-[(Piperidin-4-yl)methyl]piperidine--hydrogen chloride (1/2)

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

A solution of 4-(piperidin-1-ylmethyl)pyridine (10.0 g, 0.056 mol; prepared using a similar procedure to that described in US430491) and platinum oxide (1.5 g) in 55 mL of ethanol and 18 mL of 12 N HCl was placed under an atmosphere of hydrogen (4.1 bar, 60 psig). After 15 h, the mixture was filtered, concentrated, and residue triturated with methanol affording 9.0 g of the title compound as a bis hydrochloride salt.

Workup

  1. customprepared
  2. filtrationthe mixture was filtered
  3. concentrationconcentrated
  4. customresidue triturated with methanol affording 9.0 g of the title compound as a bis hydrochloride salt

Sources & evidence

ORD record
ord-00d2c9de405f44dda110bd9e58912917
Source dataset
uspto-grants-2004_08
Patent number
US06784182B2

Reaction notes

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