Methanol → HCID 22186100, compound

HRID 1837508Notes

Reaction equation

HRID 1837508 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][NH:10][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].I.CS[C:17]1[NH:18][CH2:19][CH2:20][N:21]=1.CO>C(OCC)C>[NH:21]1[CH2:20][CH2:19][N:18]=[C:17]1[N:10]1[CH2:9][CH2:8][C:7]2[C:12](=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[CH2:11]1

Participants

5

Reactant 3

HCID 887MethanolHCID 64248331,2,3,4-Tetrahydro-7-nitroisoquinolineHCID 122212281H-Imidazole, 4,5-dihydro-2-(methylthio)-, hydriodide (1:1)

Product 1

HCID 22186100HCID 22186100, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 10 g of 7-nitro-1,2,3,4-tetrahydroisoquinoline, 13.7 g of 2-methylsulphanyl-4,5-dihydro-1H-imidazole hydriodide and 100 ml of methanol is heated at reflux for 12 hours. The addition of diethyl ether causes the separation of a precipitate, which is taken up in water, neutralised using sodium hydroxide and extracted with dichloromethane.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 12 hours
  3. customthe separation of a precipitate, which
  4. extractionextracted with dichloromethane

Sources & evidence

ORD record
ord-47f3c703f1f645268d5060d1d6e8dd42
Source dataset
uspto-grants-2004_08
Patent number
US06784183B2

Reaction notes

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