HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 22186100, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1,2,3,4-Tetrahydro-7-nitroisoquinoline | HCID 6424833 | — |
| Reactant | 1H-Imidazole, 4,5-dihydro-2-(methylthio)-, hydriodide (1:1) | HCID 12221228 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 22186100 | HCID 22186100 | — |
Reaction Steps
A mixture of 10 g of 7-nitro-1,2,3,4-tetrahydroisoquinoline, 13.7 g of 2-methylsulphanyl-4,5-dihydro-1H-imidazole hydriodide and 100 ml of methanol is heated at reflux for 12 hours. The addition of diethyl ether causes the separation of a precipitate, which is taken up in water, neutralised using sodium hydroxide and extracted with dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06784183B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-47f3c703f1f645268d5060d1d6e8dd42 |
| Source note | uspto-grants-2004_08 |