Hydrochloric Acid → HCID 178507190, compound

HRID 1837520Notes

Reaction equation

HRID 1837520 reaction equation
C([N:20]1[CH:24]=[C:23]([CH:25]2[CH:34]3[CH:29]([CH:30]=[CH:31][C:32]([NH2:35])=[CH:33]3)[CH2:28][CH2:27][CH2:26]2)[N:22]=[CH:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.CO>C(O)(C)C.C(OCC)C>[NH:20]1[CH:24]=[C:23]([CH:25]2[CH:34]3[CH:29]([CH:30]=[CH:31][C:32]([NH2:35])=[CH:33]3)[CH2:28][CH2:27][CH2:26]2)[N:22]=[CH:21]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 22186087HCID 22186087, compound

Product 1

HCID 178507190HCID 178507190, compound

Reagents, catalysts & solvents 1

HCID 22147583Diethyl ether 2-propanolSolvent

Procedure

A mixture of 7.7 g of the product obtained in Step 3, 4.2 ml of concentrated hydrochloric acid and 100 ml of methanol is heated at reflux for 2 hours. After concentration of the solvent, the residue is taken up in an isopropanol/diethyl ether mixture. The expected product is obtained by filtering off the precipitate.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 2 hours

Sources & evidence

ORD record
ord-7b6ec8838fe142d89d1aced69bf0abbe
Source dataset
uspto-grants-2004_08
Patent number
US06784183B2

Reaction notes

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