Hydrochloric Acid → HCID 178507241, compound

HRID 1837522Notes

Reaction equation

HRID 1837522 reaction equation
C([N:20]1[CH:24]=[C:23]([CH:25]2[CH2:34][C:33]3[CH:32]=[C:31]([NH2:35])[CH:30]=[CH:29][C:28]=3[CH2:27][CH2:26]2)[N:22]=[CH:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.CO>CC(C)=O.C(OCC)C>[NH:20]1[CH:24]=[C:23]([CH:25]2[CH2:34][C:33]3[CH:32]=[C:31]([NH2:35])[CH:30]=[CH:29][C:28]=3[CH2:27][CH2:26]2)[N:22]=[CH:21]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 22186097HCID 22186097, compound

Product 1

HCID 178507241HCID 178507241, compound

Reagents, catalysts & solvents 1

HCID 21584533Acetone diethyletherSolvent

Procedure

A mixture of 5.5 g of the product obtained in Step 4, 3.8 ml of concentrated hydrochloric acid and 100 ml of methanol is heated at reflux for 2 hours. Following concentration of the solvent, the residue is taken up in an acetone/diethyl ether mixture. The precipitate is filtered off and yields the expected product.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 2 hours
  3. filtrationThe precipitate is filtered off

Sources & evidence

ORD record
ord-77266d9cc94441b9baf4085609fd9799
Source dataset
uspto-grants-2004_08
Patent number
US06784183B2

Reaction notes

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