4-Bromobiphenyl → 3-([1,1'-Biphenyl]-4-yl)prop-2-yn-1-ol

HRID 1837528Notes

Reaction equation

HRID 1837528 reaction equation
[CH2:1]([OH:4])[C:2]#[CH:3].Br[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:8][CH:7]=1>>[C:9]1([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:10]=[CH:11][C:6]([C:3]#[C:2][CH2:1][OH:4])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 71014-BromobiphenylHCID 7859Propargyl alcohol

Product 1

HCID 223207533-([1,1'-Biphenyl]-4-yl)prop-2-yn-1-ol

Procedure

In a manner described in Example 18 above, propargyl alcohol was reacted with 4-bromobiphenyl to give the title compound as white crystals: NMR (CDCl3) δ 4.53 (d, J=4.74, 2H), 7.38 (d, J=7.17, 1H), 7.42-7.60 (m, 8H). MS m/z 208 (M+ calcd. for C15H12O=208.3).

Sources & evidence

ORD record
ord-4d29a3a798814bf2b0c2e4a49951a7c5
Source dataset
uspto-grants-2004_08
Patent number
US06784184B2

Reaction notes

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