HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromopropane → HCID 22678079, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromopropane | HCID 8001 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 10298472 | HCID 10298472 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22678079 | HCID 22678079 | — |
Reaction Steps
The compound of Example 97 is reacted with 1,3-dibromopropane and potassium carbonate in DMF to give 5-[5-(4-chlorophenyl)pent-4-ynyl]-3-(3-bromopropyl)-5-(4-methoxybenzenesulfonyl)thiazolidine-2,4-dione, and this is reacted with imidazole, sodium salt in DMF, and in the presence of a catalytic amount of potassium iodide to give the title compound as a light tan solid, mp 111-113° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06784184B2 |
| Source dataset | uspto-grants-2004_08 |
| ORD ID | ord-153daa2b03af45f28d3dbb9a1b4ce4f2 |
| Source note | uspto-grants-2004_08 |