Water → Ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl)hexahydro-4-pyridinylidene]acetate
Reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].[CH3:8][O:9][C:10]1[C:15]([CH2:16][N:17]2[CH2:22][CH2:21][C:20](=O)[CH2:19][CH2:18]2)=[CH:14][CH:13]=[CH:12][N:11]=1.[OH2:24]>>[CH3:8][O:9][C:10]1[C:15]([CH2:16][N:17]2[CH2:22][CH2:21][C:20](=[CH:3][C:2]([O:1][CH2:5][CH3:4])=[O:24])[CH2:19][CH2:18]2)=[CH:14][CH:13]=[CH:12][N:11]=1Participants
Procedure
Under ice-cooling, a mixed solution of 2.2 ml of triethyl phosphonoacetate and 18 ml of tetrahydrofuran was added dropwise into a suspension of 0.40 g of 60% sodium hydride (oil suspension) and 18 ml of tetrahydrofuran. After stirring for 5 minutes, a mixed solution of 2.0 g of 1-[(2-methoxy-3-pyridyl)methyl]-4-piperidone and 9 ml of tetrahydrofuran was added dropwise thereinto. After completing the dropwise addition, the mixture was further stirred under ice-cooling for 30 minutes. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the crude product was purified by silica gel column chromatography (ethyl acetate:hexane=1:1), to give 2.6 g of the title compound as a pale yellow oil.
Workup
- temperatureUnder ice-cooling
- additionthe dropwise addition
- stirringthe mixture was further stirred under ice-
- temperaturecooling for 30 minutes
- extractionthe mixture was extracted with ethyl acetate
- washThe organic layer was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was evaporated
- customthe crude product was purified by silica gel column chromatography (ethyl acetate:hexane=1:1)
Sources & evidence
- ORD record
- ord-4a1ad0b8cb6f4df4ac9a88885656df56
- Source dataset
- uspto-grants-2004_08
- Patent number
- US06784192B2
Reaction notes
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