Hydrochloric Acid → 2-[1-[(2-Methoxy-3-pyridyl)methyl]-2-piperidyl]acetic acid

Participants

Reaction Steps

2.8 g of ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl]-2-piperidyl]acetate, 20 ml of a 2N aqueous sodium hydroxide and 20 ml of methanol were stirred at 70° C. for 1.5 hours. 8 ml of a 5N aqueous hydrochloric acid was added thereto, and the solvent was evaporated. Ethanol was added to the residue and sodium chloride was filtered off. Ethanol was evaporated, to give 2.9 g of a colorless oil.

Provenance & Evidence