Hydrochloric Acid → HCID 22678317, compound

HRID 1837701Notes

Reaction equation

HRID 1837701 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH:11]2[CH2:16][C:17]([O:19]CC)=[O:18])=[CH:7][CH:6]=[CH:5][N:4]=1.[OH-].[Na+].Cl>CO>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH:11]2[CH2:16][C:17]([OH:19])=[O:18])=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22678411HCID 22678411, compound

Product 1

HCID 22678317HCID 22678317, compoundYield 114.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.8 g of ethyl 2-[1-[(2-methoxy-3-pyridyl)methyl]-2-piperidyl]acetate, 20 ml of a 2N aqueous sodium hydroxide and 20 ml of methanol were stirred at 70° C. for 1.5 hours. 8 ml of a 5N aqueous hydrochloric acid was added thereto, and the solvent was evaporated. Ethanol was added to the residue and sodium chloride was filtered off. Ethanol was evaporated, to give 2.9 g of a colorless oil.

Workup

  1. customthe solvent was evaporated
  2. additionEthanol was added to the residue and sodium chloride
  3. filtrationwas filtered off
  4. customEthanol was evaporated

Sources & evidence

ORD record
ord-c4d4e6c2cd904111996c3897d4e4d6a1
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

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