反应详情

4 g of (2-methoxy-3-pyridyl)methyl chloride, 2.5 g of sodium cyanide and 10 ml of DMF were stirred under heating for 10 minutes. Water was added thereto, and the mixture was extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The drying agent was removed, and the solvent was evaporated. The residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1), to give 2.5 g of a colorless oil.

1. temperatureunder heating for 10 minutes
2. extractionthe mixture was extracted with ethyl acetate
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe drying agent was removed
5. customthe solvent was evaporated
6. customThe residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1)