反应详情

3.78 g of 6-methyl-2-methoxy-3-pyridinemethanol was dissolved in 60 ml of carbon tetrachloride, 6.48 g of triphenylphosphine was added thereto, and the mixture was heated under reflux for 6 hours 30 minutes. The solvent was evaporated, n-hexane was added to the residue, and the insoluble matters were filtered off. The filtrate was evaporated, and the crude product was purified by silica gel chromatography (n-hexane:ethyl acetate=100:1), to give 2.29 g of the title compound as a colorless oil.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 6 hours 30 minutes
3. customThe solvent was evaporated
4. additionn-hexane was added to the residue
5. filtrationthe insoluble matters were filtered off
6. customThe filtrate was evaporated
7. customthe crude product was purified by silica gel chromatography (n-hexane:ethyl acetate=100:1)