Hydrochloric Acid → HCID 22678413, compound

HRID 1837712Notes

Reaction equation

HRID 1837712 reaction equation
C[O:2][CH:3](OC)[C:4]1[C:5]([O:14][CH3:15])=[N:6][CH:7]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:9]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH3:13][S:10]([C:8]1[CH:9]=[C:4]([CH:3]=[O:2])[C:5]([O:14][CH3:15])=[N:6][CH:7]=1)(=[O:12])=[O:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 22678645HCID 22678645, compound

Product 1

HCID 22678413HCID 22678413, compoundYield 92.9%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

0.81 g of 5-(methylsulfonyl)-2-methoxy-3-pyridinecarboxaldehyde dimethyl acetal was dissolved in 8 ml of acetone, 2 ml of 5N-hydrochloric acid was added thereto, and the mixture was stirred at room temperature for 30 minutes. An aqueous sodium carbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, n-hexane was added to the residue and the resulting product was collected by filtration, to give 0.62 g of the title compound as a white powder.

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated
  5. additionn-hexane was added to the residue
  6. filtrationthe resulting product was collected by filtration

Sources & evidence

ORD record
ord-00123e3a36254d27ad27ebb74abdefbf
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

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