HCID 22678362, compound → HCID 22678736, compound

HRID 1837720Notes

Reaction equation

HRID 1837720 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14](/[CH:17]=[CH:18]/[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[O:25][CH2:26][CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>C(O)C.[C].[Pd]>[CH:27]1([CH2:26][O:25][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[CH2:18][CH2:17][CH:14]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]1

Participants

4

Reactant 1

HCID 22678362HCID 22678362, compound

Product 1

HCID 22678736HCID 22678736, compoundYield 98.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

554 mg of 1-(benzyloxycarbonyl)-4-[(E)-2-[(2-cyclohexylmethyloxy)phenyl]-1-ethenyl]piperidine was dissolved in 10 ml of ethanol, 250 mg of 10% palladium-carbon powder (water-containing product) was added thereto, and the mixture was stirred at room temperature under normal pressure overnight under a hydrogen atmosphere. The reaction solution was filtered and the filtrate was evaporated, to give 379 mg of the title compound as a colorless oil.

Workup

  1. filtrationThe reaction solution was filtered
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-190692121f9c41ccaa538315c167db0e
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

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